Many cats with chronic renal failure (CRF) may suffer from gastritis (inflammation of the stomach lining) as a consequence of the accumulation of waste-products in the circulation. This contributes significantly to the inappetence and weight loss associated with CRF.
CRF cats may also have a build up of a hormone called gastrin, which stimulates the production of acid in the stomach, because the kidneys are unable to excrete it effectively. The resulting excess stomach acid can be controlled with low doses of H2-antagonists such as cimetidine or ranitidine.
Sucralfate may also be recommended if the cat is suffering from gastric ulceration, although it can cause constipation in some cats.
An anti-emetic drug (one that reduces nausea and vomiting), such as metoclopramide or chlorpromazine, may also be recommended to block uraemic toxin stimulation of the stomach.